NSC 368262( NSC368262 )

Catalog No. M13923 CAS No. 299421-08-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NSC 368262
Note

Research use only, not for human use.
Brief Description

NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3.
Description

NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models.
In Vitro

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In Vivo

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Synonyms

NSC368262
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

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Indication

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CAS Number

299421-08-2
Formula Weight

410.426
Molecular Formula

C22H22N2O6
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=C(C(NC2=NC=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
Chemical Name

6-[(pyridin-2-ylamino)-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol

1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43.

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