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Home - Products - JAK/STAT Signaling - STAT - NSC 368262

NSC 368262

CAS No. 299421-08-2

NSC 368262 ( NSC368262 )

Catalog No. M13923 CAS No. 299421-08-2

NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 368262
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3.
  • Description
    NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models.
  • Synonyms
    NSC368262
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    299421-08-2
  • Formula Weight
    410.43
  • Molecular Formula
    C22H22N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=C(C(NC2=NC=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
  • Chemical Name
    6-[(pyridin-2-ylamino)-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43.
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