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NSC 368262
CAS No. 299421-08-2
NSC 368262( NSC368262 )
Catalog No. M13923 CAS No. 299421-08-2
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNSC 368262
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3.
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DescriptionNSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models.
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In Vitro——
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In Vivo——
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SynonymsNSC368262
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number299421-08-2
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Formula Weight410.426
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Molecular FormulaC22H22N2O6
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Purity>98% (HPLC)
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Solubility——
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SMILESOC1=C(C(NC2=NC=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
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Chemical Name6-[(pyridin-2-ylamino)-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43.
molnova catalog
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